cognitive ,impairment — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3S0195	Nootkatone		AMPK
	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activa...		AMPK
TN2100	Pratensein		Others , NF-κB
	Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.		Others , NF-κB
T22012	7BIO		FLT , DYRK , Aurora Kinase
	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.		FLT , DYRK , Aurora Kinase
T7530	PD146176	NSC168807	Ferroptosis , Lipoxygenase , Autophagy
	PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology...		Ferroptosis , Lipoxygenase , Autophagy
T28368	PF-04859989 HCl	PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others
	PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s...		Others
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T1406	Amantadine hydrochloride	1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor , Influenza Virus
	Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.		Dopamine Receptor , Influenza Virus
T13151L	THK5351		Others
	THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment.		Others
T31079	CP-810123	CP 810123,UNII-E6G4550EC4,CP810123	AChR
	CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease.		AChR
T16881	SIB-1553A hydrochloride		AChR
	SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzhei...		AChR
T7193	Encenicline	EVP-6124	AChR
	Encenicline (EVP-6124) is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease.		AChR
T1884	CX516	Ampakine CX516,BDP 12,Ampalex	GluR , iGluR
	CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).		GluR , iGluR
T19812	Propentofylline	HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285	PDE
	Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's d...		PDE
T77678	TZ3O		AChR
	TZ3O is an anticholinergic compound with neuroprotective activity.TZ3O ameliorates memory impairment and cognitive decay in Scopolamine-induced Alzheimer's type model in rats, and can be used in the study of Alzheimer's ...		AChR
T26834	BL-1020 Mesylate	CYP-1020 Mesylate	Dopamine Receptor , GABA Receptor
	BL-1020 Mesylate (CYP-1020 Mesylate) is an orally available GABA A receptor agonist and D2 antagonist that decreases dopamine activity and enhances GABAA activity.BL-1020 Mesylate has been used in the study of schizophre...		Dopamine Receptor , GABA Receptor
T77054	Lecanemab	BAN-2401	Beta Amyloid
	Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated β-amyloid (Abeta) with activity against oligomers, protofibrils, and insoluble protofibrils, and may be useful in the study of Alzheimer's ...		Beta Amyloid
TP1570	Cortistatin-14		Somatostatin
	Cortistatin-14, a neuropeptide structurally similar to growth inhibitor-14, has anticonvulsant and neuroprotective effects and impairs recognition memory consolidation in mice through activation of sst(2), growth hormone...		Somatostatin
T3902	Atractylenolide III	ICodonolactone,8β-Hydroxyasterolide	Apoptosis
	Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung...		Apoptosis
TN1420	Bacopaside I		Others
	Bacopaside I is a saponin isolated from Bacopa monniera. Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 ...		Others
T5702	Tenuifoliside B		Dehydrogenase
	Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassi...		Dehydrogenase